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Title   항문암의 DNA Ploidy 형태의 분석 - 예후와의 관계 ( Analysis of DNA Ploid Patterns of Anal Cancer - Correlation to the Prognosis - )
Publicationinfo   1992 Jan; 024(02): 233-239.
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Abstract   Using flow cytometric DNA analysis of paraffin embeded tissue, DNA histograms were successfully obtained from the 46 primary anal cancers patients. Analysis of DNA content in pri- mary cancers showed that 25 were diploid(54%), 4 were tetraploid(9%), and 17 were aneuploid (37%.). The ploidy patterns of metastatic lymph nodes and locally recurred lesions were similar to the primary lesions. DNA ploidy patterns were not significantly different according to the anatomical sites and the pathological stages. No statistically significant effect of DNA content on five year surviva1 could be demonstrated, but the disease free five year survival rates were significantly different according to the DNA ploidy patterns. The disease free 5 year survival rate of nondiploid anal cancer was 35% and that of diploid was 75%. The local recurrence rate of the diploid anal cancers was less than that of nondiploid anal cancer(22%: 56%). The DNA ploidy pattern of an anal cancer was one of the independent prognostic factors.
저 자   김영진(Young Jin Kim),조철균(Chol Gyoon Cho),(DeCosse JJ)